1. Pain and swelling in hands and feet
2. Fever, chest pain or episodic pain in joints, abdomen or back
3. Shortness of breath and fatigue
4. Abnormal swelling and unusual or prolonged headache
5. Any sudden weakness or less of sensation and prolonged erection
6. Sudden vision changes and loss of consciousness
7. Paleness and parvovirus which is the destruction of the bone marrow; this is aplastic crisis.
8. Pneumonia and damage to the joints especially hip and shoulder
9. Gallstones, stroke and seizures, heart murmurs or enlarged heart.
10. Delayed growth and sexual development
11. Liver disease, and high rate of hepatitis C
12. Leg ulcers and problems with thinking, memory and perfomance.
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